Long-Term Observation of Herpes Simplex Virus Type 1 (HSV-1) Infection in a Child with Wiskott-Aldrich Syndrome and a Possible Reactivation Mechanism for Thymidine Kinase-Negative HSV-1 in Humans

DOI Web Site Web Site 1 Citations
  • Shiota Tomoyuki
    Department of Virology I, National Institute of Infectious Diseases, Japan
  • Kurane Ichiro
    Department of Virology I, National Institute of Infectious Diseases, Japan
  • Morikawa Shigeru
    Department of Virology I, National Institute of Infectious Diseases, Japan
  • Saijo Masayuki
    Department of Virology I, National Institute of Infectious Diseases, Japan

Search this article

Abstract

<p>Herpes simplex virus type 1 (HSV-1) infections in a child with congenital immunodeficiency syndrome were observed over a 10-year period. The child suffered from recurrent and severe HSV-1 mucocutaneous infections. He frequently suffered from acyclovir (ACV)-resistant (ACVr) HSV-1 infection in the later phase of his life, especially after the episode of ACVr HSV-1 infection. Virological analyses on the HSV-1 isolates recovered from this patient revealed that all the ACVr HSV-1 isolates were thymidine kinase (TK)-negative (TK-) due to a single cytosine (C) deletion within the 4-C residues (positions 1061 to 1064) in the TK gene, indicating that the recurrent TK-/ACVr HSV-1 infections throughout the patient's life were due to the identical ACVr HSV-1 strain. Furthermore, it was found that the ACV-sensitive (ACVs) isolate recovered from the skin lesions that appeared between the episodes of ACVr infection at the ages of 8 and 9 contained ACVr HSV-1 with the same mutation in the TK gene. These results indicate that, although TK activity is required for reactivation of TK+/ACVs HSV-1 from latency and TK-/ACVr HSV-1 is unable to reactivate from latency, the TK-/ACVr HSV-1 strain isolated herein reactivated in this patient, possibly by using the TK activity induced by the latently co-infected TK+/ACVs HSV-1.<tt> </tt></p>

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 64 (2), 121-126, 2011-03-31

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

Citations (1)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top