Mortality Attributable to Carbapenem-Resistant Nosocomial <i>Acinetobacter baumannii</i> Infections in a Turkish University Hospital

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  • Aydemir Hande
    Department of Infectious Diseases and Clinical Microbiology, Zonguldak Karaelmas University Medical Faculty, Turkey
  • Celebi Guven
    Department of Infectious Diseases and Clinical Microbiology, Zonguldak Karaelmas University Medical Faculty, Turkey
  • Piskin Nihal
    Department of Infectious Diseases and Clinical Microbiology, Zonguldak Karaelmas University Medical Faculty, Turkey
  • Oztoprak Nefise
    Department of Infectious Diseases and Clinical Microbiology, Zonguldak Karaelmas University Medical Faculty, Turkey
  • Keskin Aysegul Seremet
    Department of Infectious Diseases and Clinical Microbiology, Zonguldak Karaelmas University Medical Faculty, Turkey
  • Aktas Elif
    Department of Microbiology, Zonguldak Karaelmas University Medical Faculty, Turkey
  • Sumbuloglu Vildan
    Department of Biostatistics, Zonguldak Karaelmas University Medical Faculty, Turkey
  • Akduman Deniz
    Department of Infectious Diseases and Clinical Microbiology, Zonguldak Karaelmas University Medical Faculty, Turkey

Bibliographic Information

Other Title
  • Mortality Attributable to Carbapenem-Resistant Nosocomial Acinetobacter baumannii Infections in a Turkish University Hospital

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Abstract

<p>This study was performed to compare the mortality associated with carbapenem-resistant<tt> </tt>Acinetobacter baumannii<tt> </tt>(CRAB) and carbapenem sensitive<tt> </tt>A. baumannii<tt> </tt>(CSAB) infections, to identify potential risk factors for CRAB infections, and to investigate the effects of potential risk factors on mortality in CRAB and CSAB patients. This retrospective case-control study was conducted in a university hospital between January 1, 2005 and December 30, 2006. One hundred and ten patients with CRAB and 55 patients with CSAB infection were identified during the study period. The mortality rate was 61.8% and 52.7% in CRAB and CSAB cases, respectively (P<tt> </tt>= 0.341). In CRAB cases, the risk factors for mortality were identified as intubation (odds ratio [OR], 3.3; 95% confidence interval [CI], 1.0–10.1;<tt> </tt>P<tt> </tt>= 0.042) and high APACHE II score (OR, 1.2; 95% CI, 1.1–1.3;<tt> </tt>P<tt> </tt>= 0.000), by multivariate analysis. Previous use of carbapenem (OR, 6.1; 95% CI, 2.2–17.1;<tt> </tt>P<tt> </tt>= 0.001) or aminopenicillin (OR, 2.5; 95% CI, 1.2–5.1;<tt> </tt>P<tt> </tt>= 0.013) were independently associated with carbapenem resistance. Although the mortality rate was higher among patients with CRAB infections, this difference was not found to be statistically significant. Previous use of carbapenem and aminopenicillin were found to be independent risk factors for infections with CRAB.</p>

Journal

  • Japanese Journal of Infectious Diseases

    Japanese Journal of Infectious Diseases 65 (1), 66-71, 2012-01-31

    National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

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