A Rare Case of Rheumatoid Arthritis with Tocilizumab-induced Intestinal Mucosal Injury
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- Ohkubo Akito
- Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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- Osoegawa Takashi
- Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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- Harada Naohiko
- Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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- Iboshi Yoichiro
- Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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- Sumida Yorinobu
- Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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- Nakamuta Makoto
- Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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- Suematsu Eiichi
- Department of Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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- Kobayashi Hiroyuki
- Department of Gastroenterology, Fukuoka Sanno Hospital, Japan
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- Ihara Eikichi
- Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan
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Description
<p>Intestinal mucosal injury that develops as a complication of tocilizumab (TCZ) is usually associated with diverticulosis. We herein report a rare case of TCZ-induced intestinal mucosal injury in the absence of diverticulosis. A 74-year-old woman suffering from rheumatoid arthritis started taking TCZ. Six months later, she complained of hematochezia and abdominal pain. Colonoscopy revealed multiple ulcers spreading from the cecum to the transverse colon but no diverticulosis. These lesions were cured at three months after the discontinuation of TCZ. We should consider TCZ as a risk factor for intestinal mucosal injury, even if patients have no history of intestinal disease associated with diverticulosis. </p>
Journal
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- Internal Medicine
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Internal Medicine 61 (7), 1011-1014, 2022-04-01
The Japanese Society of Internal Medicine
