A case of unresectable intrahepatic cholangiocarcinoma receiving sustainable pembrolizumab therapy
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- MATSUSHITA Sho
- Department of Gastroenterology, Tenri Yorozu Hospital
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- UEO Taro
- Department of Gastroenterology, Tenri Yorozu Hospital
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- MINAMI Ryuki
- Department of Gastroenterology, Tenri Yorozu Hospital
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- OZAWA Tomomi
- Department of Gastroenterology, Tenri Yorozu Hospital
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- MATSUMOTO Atsushi
- Department of Gastroenterology, Tenri Yorozu Hospital
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- KIMURA Yuto
- Department of Gastroenterology, Tenri Yorozu Hospital
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- TAKEDA Yasuhiro
- Department of Gastroenterology, Tenri Yorozu Hospital
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- OKANO Akihiro
- Department of Gastroenterology, Tenri Yorozu Hospital
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- KUSUMI Fusako
- Department of Gastroenterology, Tenri Yorozu Hospital
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- OHANA Masaya
- Department of Gastroenterology, Tenri Yorozu Hospital
Bibliographic Information
- Other Title
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- Pembrolizumabが長期に奏功している切除不能肝内胆管癌の1例
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Abstract
<p>A 65-year-old man had unresectable intrahepatic cholangiocarcinoma with a malignant biliary stricture. We used an endoscopic plastic stent to drain the bile. Despite receiving standard chemotherapy, the tumor eventually progressed and cancerous peritonitis developed. We had to exchange plastic stents frequently because of stent occlusion. We had a re-biopsy with EUS-FNA and tested for microsatellite instability, which came back as MSI-high. We administered pembrolizumab, which resulted in a significant reduction of tumor size. We were able to administer long-term chemotherapy without serious side effects by repeatedly exchanging plastic stents for stent occlusion. He has maintained partial response for more than 20 months after receiving pembrolizumab.</p>
Journal
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- Nippon Shokakibyo Gakkai Zasshi
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Nippon Shokakibyo Gakkai Zasshi 119 (4), 360-367, 2022-04-10
The Japanese Society of Gastroenterology
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Details 詳細情報について
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- CRID
- 1390010292962820224
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- ISSN
- 13497693
- 04466586
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed