Examination of blood collection tubes containing serum separation gel in blood drug concentration measurement

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  • 血中薬物濃度測定における血清分離剤入り採血管の検討
  • ケッチュウ ヤクブツ ノウド ソクテイ ニ オケル ケッセイ ブンリザイ イリ サイケツカン ノ ケントウ

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Abstract

<p>Several separation gels added to blood collection tubes have been reported to have the drug adsorption effect. In this study, we compared the degree of impact of each manufacturer’s blood collection tube as shown in the blood drug concentration measurement. During the monitoring of the time-course shifts in the drug concentration of the blood collection tubes containing a separation gel from four manufacturers, three of the eight drugs examined showed decreases in their measured concentrations. Despite the equal volume of a blood specimen added to the blood collection tubes and the same storage conditions, the degree of decrease varied depending on the blood collection tube used. Thus, the difference in the materials of a separation gel was considered as one of the factors affecting measurements. It was inferred that the variance in the degree of decrease in the measured concentration was caused by the differences in the lipophilicity of the separation gel and the drugs. In the case where a blood collection tube containing a separation gel is utilized, it is considered that the examination of the combination of the tube to be utilized and the drug to be measured can contribute to the improvement of the efficiency of blood specimen collection and processing.</p>

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