Effects of Estradiol on Expression of Estrogen Receptor and Collagen mRNAs in Chick Skin

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  • Nishimura Shotaro
    Faculty of Agriculture, Kyushu University
  • Arai Sayaka
    Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • Ohtani Mizuki
    Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • Shimomura Yuri
    Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • Tabata Shoji
    Faculty of Agriculture, Kyushu University

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<p>Skin thickness and strength differ between male and female chickens. This study aimed to clarify the effects of estradiol on the expression of estrogen receptors and collagen mRNA in chicken skin. Estradiol was administered to male chicks for 3 weeks, then cryosections of skin collected from the cervical, thoracic, dorsal, and pelvic limb regions were stained with hematoxylin and eosin, and dermal thickness was measured. Estrogen receptor and collagen mRNA expression was assessed using real-time RT-PCR, and collagen contents were determined. Estradiol did not alter dermal thickness or the collagen content of the skin from any tested region. Among the estrogen receptors, significantly more ESR1 mRNA was expressed in the thoracic skin of chicks administered with estradiol compared with vehicle (control), and in the thoracic skin compared with skin from other regions within each group. Estradiol did not affect ESR2, GPER, and COL1A1 mRNA expression. These results suggested that estradiol stimulates ESR1 expression in thoracic skin, but does not affect collagen synthesis in skin from any other region of male chicks.</p>

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