Cytogenetic Biodosimetry in Radiation Emergency Medicine: 2. Biosafety and Chemical Safety in Biodosimetry Laboratory

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  • Kasai Kosuke
    Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
  • Abe Yu
    Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan
  • Ting Valerie Goh Swee
    Department of Radiobiology, Singapore Nuclear Research and Safety Initiative, National University of Singapoore, 1 Create Way, Singapore 138602, Singapore
  • Thanh Mai Tran
    Biodosimetry Group, Centre of Radiation Technology and Biotechnology, Dalat Nuclear Research Institute, 1 Nguyen Tu Luc, Ward 8, Dalat City, Lamdong Province, Vietnam
  • Fujishima Yohei
    Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
  • Nakayama Ryo
    Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
  • Takebayashi Kai
    Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan
  • Nakata Akifumi
    Faculty of Pharmaceutical Sciences, Hokkaido University of Science, 15-4-1, Maeda 7-jo, Teine-ku, Sapporo, Hokkaido 006-8585, Japan
  • Ariyoshi Kentaro
    Center for Integrated Science and Humanities, Fukushima Medical University, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan
  • Hanada Hiroyuki
    Advanced Emergency and Critical Care Center, Hirosaki University Hospital, Hirosaki University, 53 Hon-cho, Hirosaki, Aomori 036-8563, Japan
  • Yoshida Mitsuaki A.
    Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan Institute of Chromosome Life Science, 11-5-409, Fukuokachuo 2-Chome, Fujimino-shi, Saitama 356-0031, Japan
  • Ito Katsuhiro
    Advanced Emergency and Critical Care Center, Hirosaki University Hospital, Hirosaki University, 53 Hon-cho, Hirosaki, Aomori 036-8563, Japan
  • Miura Tomisato
    Department of Risk Analysis and Biodosimetry, Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki, Aomori 036-8564, Japan

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説明

<p>In a biodosimetry laboratory, blood collected from exposed patients is cultured and the exposure dose is estimated based on the frequency of chromosome aberrations. Blood is defined as an infectious specimen because it may contain hepatitis virus and human immunodeficiency virus (HIV) and must be handled in a biosafety level (BSL) 2 facility. Due to the recent coronavirus pandemic with SARS-CoV-2, further strengthening of infection control measures is required. This article outlines the requirements for setting up a BSL2 laboratory, personal protective equipment for infection control, treatment of infectious biological waste and emergency response measures. Furthermore, it is essential to safely manage hazardous chemicals used in biodosimetry. Biodosimetry laboratories should conduct risk assessments of blood handling and chemical use and consider risk mitigation measures. In addition, laboratory personnel must educate workers on infection control and chemical safety.</p>

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