Analysis of factors affecting the antibody titer obtained after vaccination against the new coronavirus

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  • OEDA Shouhei
    Department of Clinical Laboratory, Mito Chuo Hospital, FURUJUKU Medical Group
  • KIMURA Yosuke
    Department of Clinical Laboratory, Mito Chuo Hospital, FURUJUKU Medical Group
  • FUTAKI Tomoko
    Department of Clinical Laboratory, Mito Chuo Hospital, FURUJUKU Medical Group
  • HATOGAI Natsuki
    Department of Clinical Laboratory, Mito Chuo Hospital, FURUJUKU Medical Group
  • MOTOHASHI Naomi
    Department of Clinical Laboratory, Mito Chuo Hospital, FURUJUKU Medical Group
  • SHISHIDO Mamoru
    Department of Clinical Laboratory, Mito Chuo Hospital, FURUJUKU Medical Group
  • YAMAGUCHI Ryushiro
    Department of Surgery, Mito Chuo Hospital, FURUJUKU Medical Group
  • NAKAGAWA Yuji
    Department of Surgery, Mito Chuo Hospital, FURUJUKU Medical Group

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  • 新型コロナウイルスワクチン接種後に獲得される抗体価に影響を与えうる因子の解析
  • シンガタ コロナウイルスワクチン セッシュ ゴ ニ カクトク サレル コウタイカ ニ エイキョウ オ アタエウル インシ ノ カイセキ

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Abstract

<p>We conducted research on the amount of antibody against the new coronavirus in 56 medical professionals who were vaccinated with the new coronavirus vaccine “COMIRNATY intramuscular injection” manufactured by Pfizer©. In this study, we measured the antibody titer in all the samples from the subjects using Lumipulse®G1200 and SARS-CoV-2 S-IgG measuring reagent (IC) (H.U. Frontier Co., Ltd.). Results showed that all the subjects obtained antibody titers that were higher than the cutoff value (1.0 AU/mL). The lowest antibody titer was 10.5 AU/mL, the highest antibody titer was 227.2 AU/mL, and the median was 62.2 AU/mL. We analyzed the factors that affect the antibody titer, focusing on gender, age, BMI, HBV antibody titer, and drinking/smoking habits. We found that the antibody titer was affected only by age, and the other factors did not show statistically significant differences. We suggest that it is possible to induce antibodies to SARS-CoV2 even in a person with a poor immune response to the hepatitis B vaccine. However, further detailed investigation is needed.</p>

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