dectin-1受容体の認識を介した<i>β</i>-glucanによる破骨細胞分化の制御と薬物療法の可能性
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- 有吉 渉
- 九州歯科大学 健康増進学講座 感染分子生物学分野
書誌事項
- タイトル別名
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- Regulation of osteoclast differentiation by <i>β</i>-glucan mediated by dectin-1 recognition and pharmacological application
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説明
<p>Coordinated co-stimulatory signals mediated by several immunoreceptors are important for the regulation of osteoclast differentiation. Dectin-1 is one of the pattern recognition receptors of β-glucan and is expressed on the surface of hematopoietic osteoclast precursor cells. In this review, we discuss the biological effects of β-glucans on bone-resorbing osteoclasts. Several β-glucans negatively regulate osteoclast differentiation by binding to dectin-1. Furthermore, we demonstrated the possibility of β-glucan as a candidate of osteoclast-targeting gene delivery system. Future studies concerning the relationship between the β-glucan structure and its biological effects on osteoclast are required for the development of novel pharmacological treatment for bone-related diseases.</p>
収録刊行物
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- 歯科薬物療法
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歯科薬物療法 41 (1), 11-18, 2022
日本歯科薬物療法学会
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詳細情報 詳細情報について
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- CRID
- 1390010610453218944
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- ISSN
- 18844928
- 02881012
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可