dectin-1受容体の認識を介した<i>β</i>-glucanによる破骨細胞分化の制御と薬物療法の可能性

DOI
  • 有吉 渉
    九州歯科大学　健康増進学講座　感染分子生物学分野

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  • Regulation of osteoclast differentiation by <i>β</i>-glucan mediated by dectin-1 recognition and pharmacological application

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説明

<p>Coordinated co-stimulatory signals mediated by several immunoreceptors are important for the regulation of osteoclast differentiation. Dectin-1 is one of the pattern recognition receptors of β-glucan and is expressed on the surface of hematopoietic osteoclast precursor cells. In this review, we discuss the biological effects of β-glucans on bone-resorbing osteoclasts. Several β-glucans negatively regulate osteoclast differentiation by binding to dectin-1. Furthermore, we demonstrated the possibility of β-glucan as a candidate of osteoclast-targeting gene delivery system. Future studies concerning the relationship between the β-glucan structure and its biological effects on osteoclast are required for the development of novel pharmacological treatment for bone-related diseases.</p>

収録刊行物

  • 歯科薬物療法

    歯科薬物療法 41 (1), 11-18, 2022

    日本歯科薬物療法学会

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