乳癌に対するS-1投与中に発症した鼻涙管閉塞例

大湊 久貴, 河野 通久, 山木 英聖, 熊井 琢美, 高原 幹, 片田 彰博, 林 達哉

doi:10.5631/jibirin.115.503

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タイトル別名

A Case of Nasolacrimal Duct Obstruction During S-1 Treatment For Breast Cancer
ニュウガンニタイスル S-1 トウヨチュウニハッショウシタハナルイカンヘイソクレイ

公開日: 2022

DOI

10.5631/jibirin.115.503

公開者: 耳鼻咽喉科臨床学会

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説明

<p>S-1, an oral 5-FU prodrug, is an antineoplastic agent used for the treatment of various types of cancer, including cancer of the head and neck. In addition to inflammation, infection, trauma, and iatrogenic causes, nasolacrimal duct obstruction could also be caused by S-1. Herein, we report the case of a patient with nasolacrimal duct obstruction that was suspected to be caused by S-1, and was successfully treated by endoscopic dacryocystorhinostomy (DCR). The patient, a 69-year-old woman, was initiated on treatment with S-1 as adjuvant therapy after resection of breast cancer. Four months later, she developed epiphora, and the lacrimal ducts were intubated with silicone tubes. A year later, she presented with recurrence of epiphora, and was referred to our department. We performed right DCR for nasolacrimal duct obstruction, and the epiphora improved. Although the mechanism of nasolacrimal duct obstruction caused by S-1 has not yet been clarified, otorhinolaryngologists should be aware of this condition.</p>

収録刊行物

耳鼻咽喉科臨床

耳鼻咽喉科臨床 115 (6), 503-506, 2022

耳鼻咽喉科臨床学会

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