A patient with rheumatoid arthritis who developed liver cirrhosis after increased soft drinks intake

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  • 糖質の過剰摂取により肝硬変へ進展した関節リウマチの1例
  • トウシツ ノ カジョウ セッシュ ニ ヨリ カンコウヘン エ シンテン シタ カンセツ リウマチ ノ 1レイ

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Abstract

<p>A Japanese woman in her 80s with rheumatoid arthritis (RA) was admitted for weakness, edema, and ascites. She was obese (148 cm in height, 60 kg in weight) and had a high gamma-glutamyltransferase level according to her laboratory findings before treatment. She had received methotrexate (MTX) at a dose of 6 mg/week for 1 year and 9 months. She had consumed large amounts of soft drinks (about 110 g of sugar/day) for a long time, but during the course of treatment for RA, she began drinking even more (170 g/day). Her condition improved with the discontinuation of MTX, adequate nutrition, and administration of diuretics. We diagnosed her with liver cirrhosis caused by both drug-induced hepatic injury due to MTX and by exacerbation of non-alcoholic steatohepatitis due to excessive sugar intake.</p>

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