Relationship between Plasma Total Protein or Albumin Levels and Sodium-chloride Concentration Difference

DOI

Bibliographic Information

Other Title
  • 血漿総蛋白およびアルブミン濃度とナトリウム―クロール濃度差の関係

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Description

<p>　Background: It has been reported that plasma sodium-chloride concentration difference ([Na+]－[Cl-]) decreases with a decrease in plasma total protein level ([TP]) due to an increase in [Cl-] as a compensatory response to maintain acid-base equilibrium.</p><p>　Objectives: This study aimed to verify this compensatory response.</p><p>　Methods: Overall, 156,220 datasets of [Na+], [Cl-], [TP], and albumin levels ([Alb]) were collected from biochemical blood examinations performed at Saitama Municipal Hospital for two years between 2019 and 2020. The 95％ confidence intervals for the mean of [Na+]－[Cl-], [Na+] and [Cl-] at each value of [TP] or [Alb] were calculated. Thereafter, the regression lines of [Na+]－[Cl-], [Na+], and [Cl-] with respect to [TP] or [Alb] were estimated based on these confidence intervals.</p><p>　Results: The regression lines of [Na+]－[Cl-] with respect to [TP] and [Alb] showed positive slope lines. Moreover, [Na+] and [Cl-] changed synchronously with changes in [TP] or [Alb].</p><p>　Conclusion: [Na+]－[Cl-] decreased with a decrease in [TP] or [Alb]. In addition, not only [Cl-], but [Na+] also affected [Na+]－[Cl-].</p>

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Details 詳細情報について

  • CRID
    1390010864677470336
  • DOI
    10.34363/jocp.51.5_179
  • ISSN
    24351695
    02867052
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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