Changes in urinary L-type fatty acid binding protein during polymyxin B-immobilized fiber column direct hemoperfusion therapy for acute pancreatitis after ERCP：a case report

DOI Web Site
  • Sato Eiichi
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Degawa Manaka
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Ono Takao
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Lu Hongmei
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Matsumura Daisuke
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Nomura Mayumi
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Moriyama Noriaki
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Amaha Mayuko
    Division of Nephrology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Ika Makiko
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Kato Keizo
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Endo Shinji
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shinmatsudo Central General Hospital
  • Saito Kazuhiko
    Department of Clinical Engineering, Shinmatsudo Central General Hospital
  • Abe Shintaro
    Department of Clinical Engineering, Shinmatsudo Central General Hospital
  • Munakata Tomoko
    Department of Clinical Engineering, Shinmatsudo Central General Hospital
  • Kanno Yuzo
    Department of Clinical Engineering, Shinmatsudo Central General Hospital
  • Nakamura Tsukasa
    Department of Nephrology, Kashiwa Forest Clinic

Bibliographic Information

Other Title
  • ERCP後の急性膵炎に対するpolymyxin B immobilized fiber column direct hemoperfusion（PMX-DHP）療法の治療経過を尿中L-type fatty acid binding protein（L-FABP）の推移から観察し得た1例
  • ERCP ゴ ノ キュウセイスイエン ニ タイスル polymyxin B immobilized fiber column direct hemoperfusion (PMX-DHP)リョウホウ ノ チリョウ ケイカ オ ニョウチュウ L-type fatty acid binding protein (L-FABP)ノ スイイ カラ カンサツ シエタ 1レイ

Search this article

Abstract

<p>The patient was a 63-year-old woman who had a common bile duct stone, which was removed by endoscopic retrograde cholangiopancreatography, followed by endoscopic retrograde biliary drainage. She subsequently developed acute pancreatitis, which did not improve with pancreatic enzyme inhibitor treatment. The patient developed sepsis and underwent polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP). Urinary L-type fatty acid binding protein (L-FABP) was raised (485.2μg/g Cre) before PMX-DHP, suggesting that acute kidney injury was inevitable. Therefore, continuous hemodiafiltration was performed using PMMA membrane. Urinary L-FABP decreased to 364.7μg/g Cre after the first PMX-DHP, and decreased from 177.7μg/g Cre to 5.4μg/g Cre after the second PMX-DHP. Acute pancreatitis improved and the renal function did not worsen (serum creatinine: 0.4mg/dL). In this patient, serum creatinine was normal, but urinary L-FABP was high and proximal tubular injury was observed. Therefore, acute kidney injury may be avoided by early renal replacement therapy. Additionally, urinary L-FABP may be used for early diagnosis of acute kidney injury. </p>

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top