A multicenter prospective study on the development of BRONJ after tooth extraction in patients treated with bisphosphonates
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- FUJIMORI Masaki
- Department of Oral and Maxillofacial Surgery, Kushiro Rosai Hospital
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- TORIYABE Yoshiyuki
- Department of Oral and Maxillofacial Surgery, Kaiseikai Onishi Hospital
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- KAKU Nobuhiro
- Department of Oral and Maxillofacial Surgery, Kushiro Rosai Hospital
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- SHIMAZAKI Kosuke
- Department of Oral and Maxillofacial Surgery, Kushiro Rosai Hospital
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- MIYASAWA Masayoshi
- Department of Oral and Maxillofacial Surgery, Hakodate Goryoukaku Hospital
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- MIYATE Hiroki
- Department of Oral and Maxillofacial Surgery, Hakodate Goryoukaku Hospital
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- KITADA Hideaki
- Department of Dentistry and Oral Surgery, Hakodate Central General Hospital
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- SATOH Yuji
- Department of Dentistry and Oral Surgery, Kyoaikai Hospital
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- MISAWA Hajime
- Department of Dentistry and Oral Surgery, Hakodate Kyokai Hospital
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- YAMASHITA Tetsuro
- Department of Dentistry and Maxillofacial Surgery, Keiyukai Sapporo Hospital
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- NAKAJIMA Yoritoshi
- Keiyukai Dentistry & Maxillofacial Surgery Clinic
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- HARIYA Yasushi
- Department of Oral and Maxillofacial Surgery, Teine Keijinkai Hospital
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- KOBAYASHI Ichizo
- Department of Oral and Maxillofacial Surgery, JR Sapporo Hospital
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- NISHIKATA Satoshi
- Department of Dentistry and Oral Surgery, Sapporo Higashi Tokushukai Hospital
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- TAISHI Yoshihito
- Department of Dentistry and Oral Surgery, Higashi Sapporo Hospital
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- SUGIURA Chihiro
- Department of Oral and Maxillofacial Surgery, Sapporo Tokushukai Hospital
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- KASAHARA Kazue
- Department of Oral and Maxillofacial Surgery, Hokkaido Chuo Rosai Hospital
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- ASAKA Yuichiro
- Department of Oral and Maxillofacial Surgery, Tomakomai City Hospital
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- SAKAKIBARA Noriyuki
- Department of Dentistry and Oral Surgery, Nikko Memorial Hospital
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- OKADA Masuhiko
- Department Oral and Maxillofacial Surgery, Asahikawa Red Cross Hospital
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- SHIBAYAMA Naohiro
- Department of Oral and Maxillofacial Surgery, Asahikawa City Hospital
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- SUETSUGU Hiroshi
- Department of Oral Surgery, Yoshida Hospital
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- SUZUKI Toyonori
- Department of Dentistry and Oral Surgery, Azabu Kitami Triology Hospital
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- ABE Takahiro
- Department of Dentistry and Oral Surgery, Kitami Red Cross Hospital
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- TANIMURA Akihiro
- Department of Dentistry and Oral Surgery, Hokusei Memorial Hospital
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- KUDOU Akihiro
- Department of Dentistry and Oral Surgery, Obihiro Daiichi Hospital
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- DONEN Masaki
- Department of Dentistry and Oral Surgery, Kushiro Red Cross Hospital
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- KAWAGUCHI Yasushi
- Department of Dentistry and Oral Surgery, Kushiro City General Hospital
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- NOJIMA Masanori
- Center for Translational Research, The Institute of Medical Science, The University of Tokyo
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- MAKINO Shujiroh
- Department of Oral Surgery, Hokuto Hospital
Bibliographic Information
- Other Title
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- ビスホスホネート投与患者の抜歯後BRONJ発生に関する多施設共同前向き研究
- ビスホスホネート トウヨ カンジャ ノ バッシ ゴ BRONJ ハッセイ ニ カンスル タシセツ キョウドウ マエムキ ケンキュウ
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Abstract
<p>Tooth extraction is reported as the main trigger of bisphosphonate (BP) -related osteonecrosis of the jaw (BRONJ). A method to prevent BRONJ has not been scientifically proven. The American Association of Oral and Maxillofacial Surgeons (AAOMS) differs from the International Task Force on Osteonecrosis of the Jaw with regard to the prevention of BRONJ via prophylactic withdrawal before tooth extraction. We performed a multicenter prospective study regarding the development of BRONJ after tooth extraction in BP-treated patients for the purpose of determining factors associated with the frequency of BRONJ. We extracted teeth from patients with a history of current or prior treatment with BP preparations; teeth were extracted using a common treatment protocol. The presence or absence of BRONJ and adverse events were evaluated. A total of 1,323 cases were targeted for this study; 2,371 teeth were extracted. The overall incidence of BRONJ was 1.74%; in the prophylactic withdrawal group it was 1.73%, whereas in the prophylactic non-withdrawal group it was 1.75%. Factors associated with the onset of BRONJ were sex, preparation adaptation classification, oral hygiene state, site of tooth extraction, and Denosumab usage. From analysis that considered the effect of confounding using the propensity score, prophylactic BP withdrawal did not result in a reduction of BRONJ (onset odds ratio with withdrawal: 1.13, 95%CI 0.36-3.57).</p>
Journal
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- Japanese Journal of Oral and Maxillofacial Surgery
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Japanese Journal of Oral and Maxillofacial Surgery 68 (4), 168-183, 2022-04-20
Japanese Society of Oral and Maxillofacial Surgeons
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Details 詳細情報について
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- CRID
- 1390010997581216000
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- NII Book ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL BIB ID
- 032158344
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
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- Abstract License Flag
- Disallowed