Imaging technology that enables simultaneous visualization of weak interaction interfaces and cell responses

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  • Yoshida Aiko
    Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
  • Fujioka Yoichiro
    Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
  • Amano Maho
    Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
  • Ohba Yusuke
    Department of Cell Physiology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University

Bibliographic Information

Other Title
  • 弱い相互作用のインターフェースと細胞応答の同時可視化を実現するイメージング技術

Abstract

The first biological element that materials, including biomolecules and exogenous/artificial factors, contact with is the cell membrane. The interface between the materials and the cell membrane is the first gateway for the materials. It is the place for a living organism to decide the fate of materials：to be “rejected,”“avoided,” or “tolerated.” This review will introduce high-speed live-cell atomic force microscopy to observe the material-cell membrane interface and fluorescence bioimaging to visualize cellular responses against the materials. Prospects for their correlative imaging will also be discussed. These technologies must provide a better understanding of how the strength of material-cell membrane interaction is decoded and how it determines the fate of cell and materials. In other words, they might be the basis to realize weak and specific interaction and the material symbiosis.

Journal

  • Drug Delivery System

    Drug Delivery System 37 (2), 102-111, 2022-03-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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