Utility of the labial gland biopsy for the diagnosis of AL amyloidosis

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  • MIYAMOTO Hironori
    Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences
  • TAKASHIMA Hiroyuki
    Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences
  • MORITA Maki
    Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences
  • MIZUTANI Tomomi
    Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences
  • KATO Shinichiro
    Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences
  • SHIBUYA Yasuyuki
    Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences

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  • ALアミロイドーシス診断における口唇腺生検の有用性
  • AL アミロイドーシス シンダン ニ オケル コウシンセンセイケン ノ ユウヨウセイ

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Abstract

<p>　Introduction: In cases of generalized amyloidosis, biopsies of various organs can be used to make a final diagnosis. The relevant guideline recommends performing a biopsy of fatty tissue from the abdominal wall as the first choice in patients suspected of having AL amyloidosis. While there is little mention concerning the utility of the labial gland biopsy, it is a minimally invasive procedure. We therefore performed a retrospective study to clarify the utility of the labial gland biopsy for diagnosing AL amyloidosis.</p><p>　Patients: Twenty-one patients with AL amyloidosis were included in the study. Six patients were diagnosed with primary AL amyloidosis and fifteen with AL amyloidosis secondary to multiple myeloma.</p><p>　Results: The sensitivity for pathological amyloidosis detection in the labial glands of patients with primary amyloidosis was 67% (4/6). The sensitivity of pathological amyloidosis detection in the labial glands of patients with secondary amyloidosis was 80% (12/15).</p><p>　Conclusions: The sensitivity of the labial gland biopsy was revealed to be as high as that of other tissue biopsies, and the positive rate was 80% for patients with AL amyloidosis secondary to multiple myeloma. These findings therefore suggest that the labial gland biopsy is recommended for diagnosing AL amyloidosis, especially in patients with secondary AL amyloidosis.</p>

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