書誌事項
- タイトル別名
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- Total Synthesis of Phaeosphaerides with STAT3 Inhibitory Activity
- STAT3 ソガイ カッセイ オ ユウスル Phaeosphaerideルイ ノ ゼン ゴウセイ
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<p>Phaeosphaeride A was originally isolated from the endophyte FA39 as an inhibitor of STAT3-DNA binding along with its inactive diastereomer phaeosphaeride B. Among proteins in the STAT (signal transducer and activator of transcription) family, STAT3 plays a crucial role in various cellular processes, including cell proliferation, survival, and differentiation. STAT3 could be a potential target for molecular-targeted cancer therapy because it is constantly activated in most solid tumors. Therefore, the STAT3 inhibitor phaeosphaeride A has been recognized as a promising seed compound for anticancer drug development.</p><p>After its isolation in 2006, our and other groups’ longstanding synthetic efforts toward phaeosphaeride A resulted in the total synthesis and structural revision of the natural product, which was subsequently confirmed by X-ray crystal structure analysis. In addition, a biomimetic acid-mediated transformation of phaeosphaeride A to phaeosphaeride B was successfully achieved to verify the hypothetical biosynthesis of phaeosphaeride B from phaeosphaeride A.</p><p>This article reviews the total synthesis and biological evaluations of phaeosphaerides A and B, and related molecules. Also, synthetic studies toward related natural products, including paraphaeosphaeride C, and structure-activity relationship studies of phaeosphaeride derivatives are discussed.</p>
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 80 (8), 755-765, 2022-08-01
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390011540582264960
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 032334471
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可