Recent Progress in Clinical Organ Preservation, Machine Perfusion Preservation

DOI
  • Matsuno Naoto
    Hepato-Biliary-Pancreatic & Transplantation Surgery, Asahikawa Medical University Development of Transplantation technology, Asahikawa Medical university
  • Obara Hiromichi
    Medical Organ Technology, Tokyo Metropolitan University

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Other Title
  • 臓器保存学を我が国に取り戻すために

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Abstract

<p>The shortage of donors for transplantation is a universal problem. The use of marginal donors is one source to increase supply. However, recipients with marginal donor graft experience a higher incidence of primary nonfunction and delayed graft function (DGF). Recently, ex vivo machine perfusion (MP) is used to reduce the incidence of DGF by decreasing the ischemic damaged graft. In addition, MP provides for assessing graft viability that is essential for optimal organ allocation. The original MP for kidney and liver graft were developed in our institute. The, first multi-center clinical trial (UMIN000038181) for marginal kidney transplantation in Japan has been started since 2020. The study design is short time hypothermic oxygenated end-ischemic perfusion for brain death marginal and DCD kidney graft. As a results so far, no trouble related MP were seen. All case was HD free at the time of discharge. Current status of MP is reviewed this context.</p>

Journal

  • Organ Biology

    Organ Biology 29 (2), 144-148, 2022

    The Japan Society for Organ Preservation and Biology

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