SYNTHESIS AND SOLUTION BEHAVIOR OF AMPHIPHILIC BLOCK TERPOLYMERS CONTAINING POLY[2-(N,N- DIMETHYLAMINO)ETHYL METHACRYLATE]

DOI IR (HANDLE)

Bibliographic Information

Other Title
  • ポリ[2-(N,N-ジメチルアミノ)エチルメタクリレート]含有両親媒性ブロック共重合体の合成と溶液挙動

Description

The amphiphilic ABC triblock terpolymer composed of poly(ethyleneglycol) (mPEG), Poly[2-(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA) and Poly(methyl methacrylate) (PMMA) segments (mPEGb-PDMAEMA-b-PMMA) was synthesized by an atom transfer radical polymerization. The encapsulation capability of ibuprofen with the resulting triblock terpolymers were investigated in water and the high encapsulation efficiency of ibuprofen into polymer micelle was achieved by an ionic bond formation between tertamino groups in PDMAEMA segment and carboxyl groups in ibuprofen, indicating that mPEG-b-PDMAEMAb-PMMA has a potential application for drug delivery system.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390011540582439168
  • DOI
    10.15002/00025296
  • HANDLE
    10114/00025296
  • ISSN
    24368083
  • Text Lang
    ja
  • Article Type
    departmental bulletin paper
  • Data Source
    • JaLC
    • IRDB
  • Abstract License Flag
    Allowed

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