A Case of Diffuse Hemispheric Glioma, H3 G34-mutant with PNET-like Glioblastoma Pathology

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  • PNET様膠芽腫の病理像を呈したdiffuse hemispheric glioma, H3 G34-mutantの1例
  • PNET ヨウコウガ シュ ノ ビョウリゾウ オ テイシタ diffuse hemispheric glioma, H3 G34-mutant ノ 1レイ

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Abstract

<p>  In certain cases, high-grade tumors arising in the cerebral hemispheres of young adults contain H3F3A G34R/V mutations.</p><p>  A 24-year-old woman was referred to our hospital following a tonic seizure. MRI resonance imaging revealed a mass lesion in the left frontal lobe. Preoperative radiological examinations revealed embryonal tumors and high-grade gliomas as differential diagnoses, Subsequently, craniotomy was performed. Histologically, the tumor was characteristic of glioblastoma with PNET-like morphology. Additional pyrosequencing and Sanger sequencing identified the H3.3 G34R mutation and led to a definitive diagnosis of diffuse hemispheric glioma, with the H3 G34-mutant.</p>

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