A Case of Pemphigus Vulgaris with Mucosal Erosion and Ulcer Over the Entire Length of the Esophagus

Iwatsu Riyo, Sato Masako, Kato Maiko, Yanagihara Shigeto, Oiso Naoki, Kawada Akira, Otsuka Atsushi

doi:10.11340/skinresearch.21.2_108

Bibliographic Information

Other Title

食道全長にわたって粘膜びらん・潰瘍をきたした尋常性天疱瘡の 1 例

Abstract

<p>A 52-year-old man had undergone medications of oral prednisolone and cyclosporine for pemphigus vulgaris for 7 years. Mucocutaneous bulla and erosions recurred gradually, Pemphigus Disease Area Index (PDAI) was moderate with 10 points on the skin and two points on the mucous membrane, but it was intractable. After hospitalization, sore throat and dyspnea required endoscopy. It revealed mucosal erosions, ulcers, and lacerations over the entire length of the esophagus with Dsg1 and Dsg3 antibodies elevated to 630 units and 2,540 units, respectively. The esophageal lesions were coincident with mucosal pemphigus vulgaris. Oral corticosteroids and azathioprine, plasmapheresis, and high-dose intravenous immunoglobulin reduced mucosal lesions 41 days later. Our case emphasizes the necessity of performing endoscopy to examine esophageal involvement in cases of severe mucosal pemphigus vulgaris. Moreover, aggressive initial treatment is important in severe cases. Skin Research, 21 : 108-113, 2022 </p>

Journal

Hifu no kagaku

Hifu no kagaku 21 (2), 108-113, 2022

Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Keywords

Details 詳細情報について

CRID: 1390011848897385856

DOI: 10.11340/skinresearch.21.2_108

ISSN: 18839614; 13471813

Web Site: https://search.jamas.or.jp/link/ui/2022315429

Text Lang: ja

Data Source

JaLC

Abstract License Flag: Disallowed

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