A caseof fatal lactic acidosis in a diabetic patient with sepsis

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  • 敗血症を合併した糖尿病患者の重症乳酸アシドーシスの一例

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<p>Apatient of anti-HIV and diabetic medications was admitted to the ICU withdecreased consciousness and blood pressure, complaining of chest discomfort andvomiting during hospital treatment for leg ulcer. We suspected septic shock andstarted rapid massive infusion of fluids, noradrenaline, and antibiotics, butthe patient's circulatory dynamics had not been improved, and high-flow CRRTwas also started. Suspecting the presence of B-type lactic acidosis due toanti-HIV drugs, diabetes drugs, and vitamin B1 (VB1) deficiency, we suspendedthe drugs and administered VB1 intravenously. As a result, marked improvementof lactic acidosis, securing of urine volume, and stabilization of hemodynamicswere observed. We experienced a case of fatal lactic acidosis due to infectionbased on VB1 deficiency during use of anti-HIV and diabetic drugs. Multimodaltreatments were successful to rescue this patient.</p>

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