Bactericidal effects of a new silver-based antimicrobial glass DL-7900 on the genus <i>Candida </i>and its application to denture cleansers

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  • Wakami Masanobu
    Department of Oral Function and Fixed Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Tsuzukibashi Osamu
    Department of Laboratory Medicine and Dentistry for the Compromised Patient, Nihon University School of Dentistry at Matsudo
  • Fukatsu Akira
    Department of Laboratory Medicine and Dentistry for the Compromised Patient, Nihon University School of Dentistry at Matsudo
  • Uchibori Satoshi
    Department of Oral Function and Fixed Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Asano Takashi
    Department of Oral Function and Fixed Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Konishi Yoshimi
    Department of Laboratory Medicine and Dentistry for the Compromised Patient, Nihon University School of Dentistry at Matsudo
  • Yoshizaki Satoshi
    Department of Oral Function and Fixed Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Kobayashi Taira
    Department of Oral Function and Fixed Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Komiyama Osamu
    Department of Oral Function and Fixed Prosthodontics, Nihon University School of Dentistry at Matsudo

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Other Title
  • 新規銀系抗菌ガラスDL-7900の<i>Candida</i>属真菌に対する殺菌効果と義歯洗浄剤への応用
  • 新規銀系抗菌ガラスDL-7900のCandida属真菌に対する殺菌効果と義歯洗浄剤への応用
  • シンキギンケイ コウキン ガラス DL-7900 ノ Candidaゾク シンキン ニ タイスル サッキン コウカ ト ギシ センジョウザイ エ ノ オウヨウ

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Abstract

<p>Purpose: The purpose of this study was to assess the bactericidal effects of a new silver-based antimicrobial glass DL-7900 on the genus Candida, to clarify the bactericidal mechanism, and to investigate its application to denture cleansers.</p><p>Methods: 1) Disk susceptibility tests of DL-7900 for Candida species and the microbroth dilution method for determining Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of DL-7900 for Candida albicans (C. albicans) were performed. 2) The time-dependent bactericidal effects of DL-7900 on C. albicans and the limitations on its number of times of use were investigated. 3) The bactericidal mechanism of DL-7900 on C. albicans was verified by PCR.</p><p>Results: 1) All Candida strains used in this study were sensitive to DL-7900, and MIC and MBC of DL-7900 for C. albicans were 3.9 mg/ml and 31.25 mg/ml, respectively. 2) C. albicans treated by DL-7900 for 60 minutes died out completely. The bactericidal effect of DL-7900 on biofilm-forming C. albicans was higher than that of commercial denture cleanser. Moreover, even if DL-7900 was used consecutively, the bactericidal effect did not decrease. 3) It was found that the bactericidal mechanism of DL-7900 on C. albicans was bacteriolysis.</p><p>Conclusions: Because DL-7900 showed high and long-term bactericidal activity, this material might be superior as a denture cleanser.</p>

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