A CASE OF ALLERGIC CONTACT DERMATITIS CAUSED BY DETERGENTS CONTAINING COCAMIDOPROPYL BETAINE IN WHICH AN IMPURITY WAS THE POSSIBLE CAUSATIVE AGENT
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- Iijima Shigeruko
- Hanamizuki Clinic
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- Murayama Kayo
- Hanamizuki Clinic
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- Takayama Noriko
- Hanamizuki Clinic
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- Akiyama Takumi
- Division of Environmental Chemistry, National Institute of Health Sciences
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- Sugiyama Mariko
- Skin Safety Case Information Network Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine
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- Matsunaga Kayoko
- Skin Safety Case Information Network Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine
Bibliographic Information
- Other Title
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- コカミドプロピルベタイン含有洗浄剤によるアレルギー性接触皮膚炎の1例
- ―洗浄剤に含まれる不純物が原因抗原と考えられた例―
Description
<p>Cocamidopropyl betaine (CAPB) is an amphoteric surfactant. It has several functions, including producing effervescence and washing effects, and thus, it is used in many cleansing products, such as shampoo and liquid body cleansers. Recently, it has become clear that some impurities that arise during the manufacturing process can have sensitizing effects. Herein, we report a case of allergic contact dermatitis caused by detergents containing CAPB, in which an impurity was determined to be the possible causative agent by patch testing and chemical analysis.</p><p>A 64-year-old Japanese female developed a skin rash on the hairlines of her forehead and nuchal region one month before her first visit to our clinic. Later, the rashes, which were composed of desquamative erythema, expanded to her face, neck, upper back, and chest. Patch tests produced positive results for a shampoo and liquid body cleanser (1% aq.) that she had used as well as for CAPB (1% aq.); lauramidopropyl betaine (LAPB) (1% aq.); and lauramidopropyl dimethylamine (LAPDMA) (0.05% aq.), which is an impurity of CAPB. The rashes resolved completely after we instructed her to use products without CAPB and LAPB. When issuing such instructions, clinicians should have correct knowledge about surfactants, such as the differences between cosmetic ingredient names and quasi-drug ingredient names.</p>
Journal
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- Japanese Journal of Allergology
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Japanese Journal of Allergology 71 (9), 1136-1142, 2022
Japanese Society of Allergology
