Insights from a patient with chronic lymphocytic leukemia complicating ALK<sup>+</sup> anaplastic large cell lymphoma
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- Lin Wuqiang
- Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
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- Chen Xiuli
- Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
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- Cai Zhenjie
- Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
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- Zheng Heyong
- Department of Hematology, the First Hospital of Putian City, Putian, Fujian, China.
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- Huang Hanxing
- Department of Pathology, the First Hospital of Putian City, Putian, Fujian, China.
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- Yang Huanxing
- Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
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- Hu Jianda
- Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
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- Zheng Jing
- Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
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- Asakawa Tetsuya
- Institute of Neurology, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong. China.
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Description
<p>Chronic lymphocytic leukemia (CLL) that transforms into a more aggressive lymphoma has been termed Richter syndrome (RS). CLL with T-cell neoplasia is rarely reported; those with ALK+ anaplastic large cell lymphoma (ALCL) are also exceedingly rarely reported. A 63-year-old woman from the south of China presented with generalized lymphadenectasis and fever; she already had a prior diagnosis of CLL 9 years ago. As per her current diagnosis, it was CLL with ALK+ ALCL. The two-lymph node and bone marrow biopsies presented two types of cellular groups: i) left cervical lymph node biopsy suggested CLL (Ki67: 10%), along with bone marrow biopsy exhibited enhancement of the small lymphocytes (30%) with scant cytoplasm, round or irregular cell nuclei, and massive amounts of chromatin. Large cells (< 1%) that expressed CD30 and ALK were visible; The results of immunohistochemistry were as follows: CD20 (weak positive); PAX5 (positive); CD23 and CD5 (weak positive); and CD3, CD10, and CyclinD1 (negative); ii) left supraclavicular lymph node biopsy suggested ALK+ ALCL (Ki67: 70%). The final diagnosis was CLL with ALCL. The mechanisms of this condition are not fully understood, which might be associated with chronic stimulation of T cells by CLL cells along with immune dysfunction. </p>
Journal
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- Intractable & Rare Diseases Research
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Intractable & Rare Diseases Research 11 (4), 196-201, 2022-11-30
International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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Details 詳細情報について
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- CRID
- 1390012878110244864
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- ISSN
- 2186361X
- 21863644
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed