Processing Speed Domain of Cognitive Function for Screening Early Cognitive Impairment Among Individuals With Atrial Fibrillation

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  • Wakisaka Yoshinobu
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

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Other Title
  • Association Between Atrial Fibrillation and Domain-Specific Cognitive Decline　― Insights From the Systolic Blood Pressure Intervention Trial ―

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<p>Background: There is a dearth of evidence to characterize longitudinal changes in domain-specific cognitive function related to atrial fibrillation (AF).</p><p>Methods and Results: This study enrolled 2,844 participants from the Systolic Blood Pressure Intervention Trial (SPRINT). Cognitive function was assessed at baseline and biennially during the follow-up period. Declines in global function and 4 major cognitive domains (i.e., memory, processing speed, language, and executive function) were fitted and compared between participants with and without AF using robust linear mixed-effect models. There were 252 participants with prevalent AF (mean [±SD] age 72.0±8.5 years; 30% women) and 2,592 participants without AF (mean age 67.9±8.4 years; 38% women). The annual decline in global function scores was greater among participants with than without AF (−0.016 vs. −0.012 points); however, the difference was not statistically significant (P=0.33). Processing speed declined faster in participants with prevalent AF, with a distinct difference of –0.013 points/year (95% CI −0.024~−0.001 points/year; P=0.02). For the memory, executive function, and language domains, there were no significant differences in the rate of cognitive decline between participants with and without AF.</p><p>Conclusions: In this post hoc analysis of the SPRINT trial, processing speed was the most prominent cognitive domain affected by AF, which may be beneficial for the early screening of cognitive dysfunction.</p>

Journal

  • Circulation Journal

    Circulation Journal 87 (1), 27-28, 2022-12-23

    The Japanese Circulation Society

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