Exercise and the Brain : A Journey from the Exercise‐Glucocorticoid Paradox

DOI
  • Chong Chen
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine
  • Nakagawa Shin
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine

Bibliographic Information

Other Title
  • The Exercise‐Glucocorticoid Paradoxからみた運動と脳機能

Abstract

Glucocorticoid, also known as a “stress hormone”, has been considered to play a central mediator role in the detrimental effects of chronic stress on the brain, cognition, and mental health. Yet, physical exercise, despite activating the HPA axis and increasing glucocorticoid, exerts many beneficial effects to the brain, cognition, and mental health. Here, we will introduce this Exercise‐Glucocorticoid Paradox and propose three potential solutions to the paradox, 1) , exercise buffers the HPA‐axis response to novel stressors, 2) , exercise does not downregulate or even increases glucocorticoid receptors, and 3) , exercise increases medial prefrontal dopamine. Via examining the Exercise‐Glucocorticoid Paradox, we hope to provide an opportunity to reconsider the functional role of glucocorticoid in stress coping and in the pathophysiology of chronic stress and depression.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390013087507370112
  • DOI
    10.11249/jsbpjjpp.33.4_160
  • ISSN
    21866465
    21866619
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

Report a problem

Back to top