δオピオイド受容体作動薬KNT-127のノンレム睡眠に対する作用

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  • Effects of KNT-127, a delta opioid receptor agonist, on non-REM sleep in mice.

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<p>Recently we have shown that delta opioid receptor agonists (DORs) shorten sleep time during the light period. However, the impact of DOR agonists on sleep quality has not been determined. In the present study, we investigated the effects of the DOR agonist KNT-127 on delta wave power (1-4 Hz), which is an indicator of non-rapid eye movement (REM) sleep depth. The vigilance states (e.g., wakefulness, REM and non-REM sleep) of the ddY-mice (6-10 weeks) were classified based on the hippocampal local field potential (LFP) and neck muscle electromyogram. KNT-127 (10-30 mg/kg, i.p.) significantly decreased the mean REM and non-REM sleep periods, and prolonged the mean wakefulness period during 5 hr after its injection. KNT-127 significantly increased delta wave power during non-REM sleep compared to saline, and this effect was also observed at 3 mg/kg without the arousal. KNT-127 (3 mg/kg), when administered in the urethane-anesthetized mice, increased delta wave power, indicating that the action is not a rebound due to sleep suppression. Together, KNT-127 promotes deeper non-REM sleep independently of its arousal effects.</p>

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