EVALUATION OF AN ALGORITHM FOR STEM CELL MOBILIZATION WITH COMBINED ON-DEMAND PLERIXAFOR USE IN AUTOLOGOUS PERIPHERAL BLOOD STEM CELL COLLECTION

DOI Web Site 23 References Open Access
  • Yamashita Kanako
    Division of Transfusion Medicine and Cell Therapy, The Jikei University Hospital
  • Sato Tomohiko
    Division of Transfusion Medicine and Cell Therapy, The Jikei University Hospital
  • Ishibashi Miyuki
    Division of Transfusion Medicine and Cell Therapy, The Jikei University Hospital
  • Ishii Kenichiro
    Division of Transfusion Medicine and Cell Therapy, The Jikei University Hospital
  • Horiguchi Shingo
    Division of Transfusion Medicine and Cell Therapy, The Jikei University Hospital
  • Gunji Tadahiro
    Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine
  • Ishii Hiroto
    Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine
  • Yokoyama Hiroki
    Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine
  • Saito Takeshi
    Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine
  • Yano Shingo
    Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine
  • Tasaki Tetsunori
    Division of Transfusion Medicine and Cell Therapy, The Jikei University Hospital

Bibliographic Information

Other Title
  • 自家末梢血幹細胞採取におけるplerixafor併用幹細胞動員アルゴリズムの検証

Search this article

Description

<p>Background: To promote the judicious use of plerixafor (PLX), our institution implemented an original algorithm for autologous stem cell mobilization in combination with on-demand PLX use (PLX-A), in which PLX is administered to patients with preceding-day peripheral blood CD34-positive cell (PBCD34+) counts below 20 cells/μl and therefore at risk of poor mobilization.</p><p>Methods: Twenty-five cases in the pre-PLX-A period and 31 cases in the post-PLX-A period were included. Rates of successful one-day collection, namely with CD34+yields ≥ 2×106/kg, in these two periods were compared. Further, associations of success rates with the preceding-day PBCD34+measurements and PLX administration among the post-PLX-A cases were retrospectively investigated.</p><p>Results: Successful one-day collection rate was significantly higher in the post-PLX-A cases than in the pre-PLX-A cases (48% vs 77%, p=0.03). Among 14 post-PLX-A cases with PBCD34+measurement, success rates of nine non-PLX-administered and five PLX-administered cases were 100% and 80%, respectively, while that of 15 post-PLX-A cases with neither PBCD34+measurement nor PLX administration was 60%. The PLX-A was not applied to three cases, although all of these cases had successful one-day collection.</p><p>Conclusions: The PLX-A was useful for improving the successful one-day collection rate. However, six of seven post-PLX-A cases with unsuccessful one-day collection did not have PBCD34+measurement, indicating underestimation of poor mobilization risk. These results suggest the need to revise the current PLX-A.</p>

Journal

References(23)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top