Prevalence of Inherited Jaundice by 10-year Follow Up Study

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  • 10年間の観察からみた体質性黄疸の頻度
  • 10ネンカン ノ カンサツ カラ ミタ タイシツセイ オウダン ノ ヒンド

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<p>Objective: Inherited hyperbilirubinemia is almost a Gilbert’s syndrome, which is fluctuated by infection, stress, and fasting. The diagnosis of Gilbert’s syndrome using the bilirubin level of one sample is unclear. I examined the prevalence of inherited jaundice in Japanese by 10-year follow up.</p><p>Methods: The participants were 772 men and 1,039 women without liver dysfunction and anemia who visited the Kouseiren Takaoka Health Care Center in 2010. The participants were followed up for 10 years. The minimum and maximum levels and fluctuation range of total bilirubin in 10 years were calculated. The participants were divided into the < 1.0 mg/dL and > 1.1 mg/dL groups, according to the maximum total bilirubin level.</p><p>Results: In the < 1.0 mg/dL group, the mean total bilirubin levels were 0.66 ± 0.13mg/dL and 0.65 ± 0.13mg/dL in men and women, respectively, with no significant difference. The mean fluctuation ranges of total bilirubin were 0.33 ± 0.19mg/dL and 0.24 ± 0.17mg/dL in men and women, respectively, with a significant difference (p<0.001). The prevalence of hyperbilirubinemia with > 1.1 mg/dL max total bilirubin level were 42.1% and 24.5% in men and women, respectively. The fluctuation bilirubin levels of hyperbilirubinemia were 0.2 to 3.4mg/dL in men and 0.3 to 2.6 mg/dL in women.</p><p>Conclusions: Assuming that the upper limit of the normal total bilirubin level was 1.0 mg/dL, the prevalence of inherited jaundice was thought to be higher than those in previous studies.</p>

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