Effect of urolithin A on Japanese cedar allergic rhinitis in mice

Morishita Nobuo, Nakatani Sachie, Shimizu Hiromu, Hayashi Kazumi, Ishikawa Katsuhiro, Ozawa Natsuko, Kudoh Mistake, Ukawa Yuichi, Kobata Kenji

doi:10.32153/ffr.ffr18_p57-64

<p>Urolithin (U) is a group of metabolites of ellagic acid (EA) and has antioxidant activity. In this study, we investigated the effect of U analogs (UA, UB, UC, UD, and UH) and EA on type1 hypersensitivity in vitro and in vivo. UA, UB, UC, and UH inhibited the release of β-hexosaminidase, an indicator of degranulation, from sensitized RBL-2H3 cells stimulated with DNP-albumin. Next, we evaluated the effect of UA on allergic symptoms in a mouse model of Japanese cedar pollinosis. BALB/c female mice were intraperitoneally injected with Japanese cedar pollen antigen as primary sensitization 3 times for 3 weeks. Further antigen was administered intranasally as secondary sensitization with or without UA for 19 days. Dexamethasone (Dex) was used as a positive control. The number of sneezes and eosinophils in the UA and Dex administration groups decreased significantly compared to the control group. Serum IgE levels were not different among the three groups. In conclusion, oral intake of UA suppresses sneezing and eosinophil migration. These suppressions might be caused by inhibition of mast cell degranulation.</p>

Effect of urolithin A on Japanese cedar allergic rhinitis in mice

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