Effect of urolithin A on Japanese cedar allergic rhinitis in mice

  • Morishita Nobuo
    Graduate School of Pharmaceutical Sciences, Josai University
  • Nakatani Sachie
    Graduate School of Pharmaceutical Sciences, Josai University Department of Pharmacy and Pharmaceutical Sciences, Josai University
  • Shimizu Hiromu
    Graduate School of Pharmaceutical Sciences, Josai University
  • Hayashi Kazumi
    Department of Pharmacy and Pharmaceutical Sciences, Josai University
  • Ishikawa Katsuhiro
    Graduate School of Pharmaceutical Sciences, Josai University
  • Ozawa Natsuko
    Department of Pharmacy and Pharmaceutical Sciences, Josai University
  • Kudoh Mistake
    DAICEL CORPORATION
  • Ukawa Yuichi
    DAICEL CORPORATION
  • Kobata Kenji
    Graduate School of Pharmaceutical Sciences, Josai University Department of Pharmacy and Pharmaceutical Sciences, Josai University

Bibliographic Information

Other Title
  • ウロリチンAの摂取が花粉症モデルマウスのアレルギー症状に与える影響

Search this article

Abstract

<p>Urolithin (U) is a group of metabolites of ellagic acid (EA) and has antioxidant activity. In this study, we investigated the effect of U analogs (UA, UB, UC, UD, and UH) and EA on type1 hypersensitivity in vitro and in vivo. UA, UB, UC, and UH inhibited the release of β-hexosaminidase, an indicator of degranulation, from sensitized RBL-2H3 cells stimulated with DNP-albumin. Next, we evaluated the effect of UA on allergic symptoms in a mouse model of Japanese cedar pollinosis. BALB/c female mice were intraperitoneally injected with Japanese cedar pollen antigen as primary sensitization 3 times for 3 weeks. Further antigen was administered intranasally as secondary sensitization with or without UA for 19 days. Dexamethasone (Dex) was used as a positive control. The number of sneezes and eosinophils in the UA and Dex administration groups decreased significantly compared to the control group. Serum IgE levels were not different among the three groups. In conclusion, oral intake of UA suppresses sneezing and eosinophil migration. These suppressions might be caused by inhibition of mast cell degranulation.</p>

Journal

Details 詳細情報について

Report a problem

Back to top