The Expression of Insulin-Like Growth Factor II Messenger RNA-Binding Protein 3 Upregulated in Intradural Extramedullary Schwannomas
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- Bekki Hirofumi
- Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University
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- Matsumoto Yoshihiro
- Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University
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- Yoshimoto Masato
- Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University
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- Ishihara Shin
- Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University
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- Kawaguchi Kenichi
- Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University
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- Yamamoto Hidetaka
- Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University
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- Oda Yoshinao
- Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University
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- Nakashima Yasuharu
- Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University
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- Harimaya Katsumi
- Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University Department of Orthopaedic Surgery, Kyushu University Beppu Hospital
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説明
<p>Introduction: Tumor size is an important factor in determining the appropriate clinical management of intradural-extramedullary schwannoma. A tumor volume reduction may be achieved by conservative targeted therapy instead of invasive surgery if a molecular event related to tumor size is discovered. Insulin-like growth factor II messenger RNA-binding protein 3 (IMP3), an oncofetal tumor-associated antigen that is expected to be a target for immunotherapy, was focused on in this study.</p><p>Methods: The IMP3 status was assessed by immunohistochemistry in 64 samples of intradural-extramedullary schwannoma, and the correlation between IMP3 expression and tumor size was evaluated.</p><p>Results: Immunohistochemically, high IMP3 expression was observed in ~85% of schwannomas. The maximum tumor diameter of the high IMP3 expression group was significantly larger than that of the low IMP3 expression group (34.3 mm vs 18.5 mm, p=0.002). The receiver operating characteristic curve demonstrated that a maximum tumor diameter of 24 mm was a predictable factor for IMP3 expression (sensitivity, 0.7; 1−specificity, 0.2; area under the curve, 0.82).</p><p>Conclusions: Upregulated IMP3 expression was associated with large tumor size, suggesting a possible therapeutic approach.</p>
収録刊行物
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- Spine Surgery and Related Research
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Spine Surgery and Related Research 7 (1), 36-41, 2023-01-27
一般社団法人 日本脊椎脊髄病学会
