Lymphoplasmacytic lymphoma accompanied by severe myelofibrosis

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  • TAKARADA Ayako
    Department of Hematology, University of Tsukuba Hospital
  • MOMOSE Haruka
    Department of Hematology, University of Tsukuba Hospital
  • KURITA Naoki
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba
  • MATSUOKA Ryota
    Department of Diagnostic Pathology, University of Tsukuba Hospital
  • NAKAMURA Naoya
    Department of Pathology, Tokai University School of Medicine
  • SAKAMOTO Tasuhiro
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba
  • KATO Takayasu
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba
  • HATTORI Keiichiro
    Department of Hematology, University of Tsukuba Hospital
  • SUEHARA Yasuhito
    Department of Hematology, University of Tsukuba Hospital
  • YOKOYAMA Yasuhisa
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba
  • NISHIKII Hidekazu
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba
  • MARUYAMA Yumiko
    Department of Hematology, University of Tsukuba Hospital
  • OBARA Naoshi
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba
  • CHIBA Shigeru
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba
  • SAKATA-YANAGIMOTO Mamiko
    Department of Hematology, University of Tsukuba Hospital Department of Hematology, Faculty of Medicine, University of Tsukuba

Bibliographic Information

Other Title
  • 高度な骨髄線維化を認めたリンパ形質細胞性リンパ腫
  • 高度な骨髄線維化を認めたリンパ形質細胞性リンパ腫 : 第16回日本血液学会関東甲信越地方会 奨励賞論文
  • コウド ナ コツズイ センイカ オ ミトメタ リンパ ケイシツ サイボウセイ リンパシュ : ダイ16カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ショウレイショウ ロンブン

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Abstract

<p>A 61-year-old female was referred to our hospital because of pancytopenia and febrile neutropenia. On admission, computed tomography showed mild hepatosplenomegaly and intra-abdominal abscess formation in the right pelvic region; however, no lymphadenopathy was found. Bone marrow (BM) examination showed severe fibrosis by silver staining. Several small- to medium-sized lymphocytes with a constriction in the nuclei were observed, exhibiting CD3 (−), CD10 (−), CD20 (+), BCL-2 (+−), and CD138 (+−). Genetic testing revealed that BM cells were positive for MYD88 mutation and positive for IgH rearrangement, whereas neither JAK2 nor CALR mutation was positive. A diagnosis of BM infiltration of lymphoplasmacytic lymphoma (LPL) was made. Rituximab monotherapy was administered once a week for four times. BM examination 4 weeks after the end of treatment showed that lymphoma cells had disappeared and that myelofibrosis had been almost gone. The MYD88 mutation of BM turned out to be negative at that moment.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 64 (1), 54-59, 2023

    The Japanese Society of Hematology

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