PREDICTORS OF EARLY AND LATE MORTALITY AFTER THE TREATMENT FOR EARLY GASTRIC CANCERS
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- OGATA Yohei
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- HATTA Waku
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- OHARA Yuki
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- KOIKE Tomoyuki
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- ABE Hiroko
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- SAITO Masahiro
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- JIN Xiaoyi
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- KANNO Takeshi
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- UNO Kaname
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- ASANO Naoki
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- IMATANI Akira
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
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- YAMAMURA Akihiro
- Department of Surgery, Tohoku University Graduate School of Medicine.
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- TANAKA Naoki
- Department of Surgery, Tohoku University Graduate School of Medicine.
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- KAMEI Takashi
- Department of Surgery, Tohoku University Graduate School of Medicine.
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- UNNO Michiaki
- Department of Surgery, Tohoku University Graduate School of Medicine.
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- NAKAMURA Tomohiro
- Department of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University.
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- NAKAYA Naoki
- Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University.
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- MASAMUNE Atsushi
- Division of Gastroenterology, Tohoku University Graduate School of Medicine.
Bibliographic Information
- Other Title
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- 早期胃癌治療後の早期・後期死亡関連因子
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Abstract
<p>Objectives: Although many patients with early gastric cancers (EGCs) die of non-gastric cancer-related causes, the association of the risk categories of lymph node metastasis (LNM) with all-cause mortality remains unclear. We aimed to clarify the predictors of early and late mortality, separately.</p><p>Methods: Patients with endoscopic resection or gastrectomy for EGCs between 2003 and 2017 were retrospectively enrolled. We analyzed predictors for early and late mortality, including risk categories of LNM, treatment method, and nine non-cancer-related indices, separately, with a cut-off value of 3 years.</p><p>Results: We enrolled 1439 patients with a median follow-up period of 79 months. The 5-year overall survival rate was 86.8%. In the multivariate Cox analysis, the most important predictors for early and late mortality were age ≥85 years (hazard ratio [HR] 2.88 and 4.54, respectively) and Eastern Cooperative Oncology Group Performance Status ≥2 (HR 3.00 and 4.19, respectively). Charlson comorbidity index ≥2 (HR 2.76 and 1.99, respectively), American Society of Anesthesiologists Physical Status ≥3 (HR 2.35 and 1.79, respectively), and C-reactive protein/albumin ratio ≥0.028 (HR 2.30 and 1.58, respectively) were also predictors for both early and late mortality. Male (HR 2.26), intermediate- (HR 2.12)/high-risk (HR 1.85) of LNM in eCura system, and sarcopenia evaluated by the psoas muscle mass index (HR 1.70) were predictors for early mortality.</p><p>Conclusion: The combined assessment of multiple predictors might help to predict early and/or late mortality in patients with EGCs. The eCura system was associated with early mortality</p>
Journal
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- GASTROENTEROLOGICAL ENDOSCOPY
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GASTROENTEROLOGICAL ENDOSCOPY 65 (2), 162-172, 2023
Japan Gastroenterological Endoscopy Society
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Details 詳細情報について
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- CRID
- 1390013706734806528
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- ISSN
- 18845738
- 03871207
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed