Development of mucosal vaccine based on DDS

DOI Web Site 46 References
  • Hosomi Koji
    Center for Vaccine and Adjuvant Research and Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition （NIBIOHN）
  • Kunisawa Jun
    Center for Vaccine and Adjuvant Research and Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition （NIBIOHN） Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, and Graduate School of Science, Osaka University International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo Graduate School of Medicine, Kobe University Research Organization for Nano and Life Innovation, Waseda University

Bibliographic Information

Other Title
  • DDSに立脚した粘膜ワクチンの開発

Abstract

Mucosal vaccines, in which vaccination is administered through mucosal （e.g., oral and nasal） routes, are attracting attention. Applications of delivery system and adjuvant are prerequisite for the practical use of mucosal vaccines. Delivery systems based on polymers, nanogels, lipids, and microbial components can promote delivery efficacy and extend the retention of vaccine antigens into mucosal tissues, resulting in the enhanced vaccine efficacy. In addition to delivery functions, adjuvant functions that can control immune responses such as activation of antigen presenting cells and induction of appropriate T cell responses are required to develop more effective vaccines. Here, we would like to introduce the development of next-generation delivery systems that can impart appropriate functions to various vaccine targets.

Journal

  • Drug Delivery System

    Drug Delivery System 37 (5), 412-420, 2022-11-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

References(46)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top