Revisions of the clinical practice guidelines for hepatocellular carcinoma in 2021 version

  • Takemura Nobuyuki
    Department of Surgery, Hepato-Biliary Pancreatic Surgery Division, National Center for Global Health and Medicine
  • Tateishi Ryosuke
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
  • Yamashita Tatsuya
    Department of Gastroenterology, Kanazawa University Hospital
  • Watadani Takeyuki
    Department of Radiology, Graduate School of Medicine, The University of Tokyo
  • Kaibori Masaki
    Department of Surgery, Hirakata Hospital, Kansai Medical University
  • Kubo Shoji
    Department of Hepato-Biliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine
  • Shimada Mitsuo
    Department of Digestive and Transplant Surgery, Tokushima University Hospital
  • Nagano Hiroaki
    Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine
  • Hatano Etsuro
    Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University
  • Aikata Hiroshi
    Department of Medicine and Molecular Science, Hiroshima University Hospital
  • Iijima Hiroko
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine
  • Ueshima Kazuomi
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine
  • Ohkawa Kazuyoshi
    Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute
  • Genda Takuya
    Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital
  • Tsuchiya Kaoru
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Torimura Takuji
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine
  • Ikeda Masafumi
    Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East
  • Furuse Junji
    Department of Gastroenterology, Kanagawa Cancer Center
  • Akahane Masaaki
    Department of Radiology, School of Medicine, International University of Health and Welfare
  • Kobayashi Satoshi
    Department of Quantum Medical Technology, Kanazawa University Graduate School of Medical Sciences
  • Sakurai Hideyuki
    Department of Radiation Oncology, University of Tsukuba Faculty of Medicine
  • Takeda Atsuya
    Radiation Oncology Center, Ofuna Chuo Hospital
  • Murakami Takamichi
    Department of Radiology, Kobe University Graduate School of Medicine
  • Motosugi Utaroh
    Department of Diagnostic Radiology, Kofu Kyoritsu Hospital
  • Matsuyama Yutaka
    Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo
  • Kudo Masatoshi
    Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine
  • Hasegawa Kiyoshi
    Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo

Bibliographic Information

Other Title
  • 肝癌診療ガイドライン2021年版の改訂点
  • カンガン シンリョウ ガイドライン 2021ネンバン ノ カイテイテン

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Abstract

<p>The clinical practice recommendations for hepatocellular carcinoma were revised in 2021. In this revision, another algorithm was introduced in the surveillance algorithms to first conduct EOB-MRI imaging after a nodule is identified by ultrasound. In the treatment algorithm, resection and ablation are suggested equally for single hepatocellular carcinoma less than 3 cm in diameter, and resection is advised first for vascular invasion-positive hepatocellular carcinomas, followed by systemic therapy for unresectable cases, and then by hepatic arterial infusion chemotherapy and TACE equally. A new algorithm or systemic therapy has been developed to complement the treatment algorithm as the number of systemic therapies for hepatocellular carcinoma has greatly risen since the last revision. Furthermore, the combination of systemic therapy and TACE, which was weakly recommended in the previous edition, has been revised to a weak recommendation in the present revision.</p>

Journal

  • Kanzo

    Kanzo 64 (3), 109-121, 2023-03-01

    The Japan Society of Hepatology

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