Allergy prevention by intervening intestinal microbiota

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  • 腸内細菌叢への介入によりアレルギーは予防できるのか

Abstract

<p>Allergy is an immunologic reaction to an innocuous antigen. Therefore, its main sites are the skin and mucosa, which are the interface between the inside and outside of the body. The intestinal microbiota has a symbiotic relationship with the human host, influencing the immunologic reaction by acting on the immune cells of the intestinal tract, and also affecting the barrier function by acting on the intestinal epithelium. Abundant factors associated with the development of allergic diseases indicate the involvement of the intestinal microbiota, and the intestinal microbiota are implicated in the development of allergy. However, the clinical question of whether intervention to the intestinal microbiota can prevent allergy is not easy to answer. Some systematic reviews suggest that probiotics may have a preventive effect on atopic dermatitis. However, current guidelines to allergic diseases do not recommend probiotics or prebiotics for prevention, because of insufficient evidence. Although the conditions for intervention with intestinal microflora are not inconclusive at present, results of future studies are highly anticipated.</p>

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