Food allergies in adulthood: gibberellin-regulated protein allergies and poly-γ-glutamic acid allergy

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  • 成人の食物アレルギー：ジベレリン制御タンパクアレルギーと納豆ポリガンマグルタミン酸アレルギー

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<p>Gibberellin-regulated proteins (GRPs) are known as a causative allergen for severe fruit allergies. To date, five GRPs, including Peach Prup 7, Ume Pru m 7 and Orange Cit s 7, have been registered internationally. GRPs are resistant to heat and digestive enzymes. GRPs cause the clinical form of food-dependent exercise-induced anaphylaxis due to the involvement of cofactors such as exercise. Clinically, eyelid edema and laryngeal tightness are frequently observed. We should pay attention to false-negative results for allergen sources in specific IgE antibody measurements. In recent years, GRPs derived from Japanese cedar pollen Cry j 7 and cypress pollen Cup s 7 have been identified. The recent reports suggested that cross-reactivity between fruit GRPs and Cry j 7 could result in pollen-food allergy syndrome.</p><p>Natto allergy is representative of late-onset anaphylaxis, which usually develops about half a day after ingestion. Patients frequently develop generalized urticaria, dyspnea, even hypotension and loss of consciousness. The major allergen is poly-γ-glutamic acid (PGA), which consists of mucilage of natto. The route of sensitization to PGA is presumed to be skin due to jellyfish sting. Interestingly, approximately 90% of natto-allergic patients have a history of marine sports.</p>

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