Shellfish Allergy

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  • Hiraguchi Yukiko
    Pediatrics, Center of Allergy and Clinical Immunology, Department of Pediatrics, Osaka Saiseikai Nakatsu Hospital

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  • 甲殻類アレルギー

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<p>Crustaceans belong to the subphylum Crustacea of the phylum Arthropoda, and include shrimp, crabs, and mantis shrimp. The 2022 National Monitoring Survey of Immediate Type Food Allergy ranked crustaceans as the eighth most likely food to cause food allergies in people of all ages, and the first and second most likely food to cause first-case allergies in 7-17 year olds and those older than 18 years, respectively. Most allergy cases occur after school age. Immediate-type symptoms are common. Crustaceans frequently cause food-dependent exercise-induced anaphylaxis. Prognosis is largely unreported, but tolerance acquisition is thought to be low. The major allergen in the crustacean subphylum is considered to be tropomyosin, but other allergens such as arginine kinase, myosin light chain, and myofibrillar calcium-binding protein have been reported. These components have high amino acid sequence homology in the arthropod phylum, and cross-antigenicity has been confirmed not only within the crustacean subphylum, but also between the chelicerata and hexapod subphyla of the arthropod phylum and the crustacean subphylum. Specific IgE antibody tests for crude antigens are insufficient both sensitivity and specificity, and the utility of component-specific IgE antibody tests is being investigated, but there are many other issues, including regional differences.</p>

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