Clinical study of lymph node metastasis without neck dissection classification in oral cancer

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  • Naruse Tomofumi
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences
  • Furukawa Kohei
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences
  • Omori Keisuke
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences
  • Miyoshi Taro
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences
  • Otsuru Mitsunobu
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences
  • Umeda Masahiro
    Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences

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  • 当科における口腔癌における舌リンパ節・咽頭後リンパ節転移例の後ろ向き観察研究

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Abstract

Metastasis to lymph nodes from oral squamous cell carcinoma （OSCC） without neck dissection classification （lingual lymph nodes （LLN） and lateral retropharyngeal lymph nodes （LRPN）） is rare and difficult to deal with. The aim of the present study was to assess the treatment modality and prognosis of LLN and LRPN in patients diagnosed with OSCC. <br>This retrospective study involved a chart review of the clinical records of OSCC patients diagnosed with LLN or LRPN metastasis between June 2008 and March 2021. Data were collected and treatment outcomes were analyzed. <br>Two OSCC patients with primary LRPN metastasis underwent LRPN dissection or superselective intra-arterial chemoradiotherapy. One patient with recurrent lateral LLN underwent surgery. Seven patients with recurrent LRPN and 7 patients with recurrent para-hypoid lymph nodes underwent chemoradiotherapy, bioradiotherapy, immune checkpoint inhibitors （ICIs） or best supportive care. The cumulative 1-year overall survival rate was 25.8％ on LLN （especially para-hyoid lymph node）, and 33.3％ on LRPN. <br>Cetuximab or ICIs are important to determine an effective treatment strategy for LLN or LRPN metastasis in the future.

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