A Case of Multiple Neuroendocrine Tumors in the Small Intestine

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  • Nakanishi Yoshiyuki
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Mizuuchi Yusuke
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Mitsubuchi Haruka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Watanabe Kan
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Tamura Kouji
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Sada Masashi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Nagayoshi Kinuko
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Nagai Shuntaro
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
  • Koga Yutaka
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University
  • Oda Yoshinao
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University
  • Nakamura Masafumi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University

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Other Title
  • 小腸に多発した神経内分泌腫瘍の1例

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<p>A 64-year-old man with alcoholic cirrhosis was referred to our hospital because of wall thickening in the terminal ileum found by CT scan performed to investigate the cause of right lower abdominal pain and bloody stools. Capsule endoscopy and double-balloon endoscopy showed multiple submucosal tumors (SMTs) in the middle to lower small intestine. Histological examination of the SMTs demonstrated proliferation of atypical cells having round shaped nuclei and eosinophilic cytoplasm, arranged in a nested pattern. Neuroendocrine tumor (NET) in the ileum was diagnosed and surgery was performed. Intraoperative findings revealed multiple tumors located in the ileum 315 cm to 365 cm from the Treitz ligament, and partial resection of the small intestine was performed. In addition, intraoperative endoscopy showed tumors in six other locations, and so wedge resection of the tumors was performed to avoid nutritional disturbance and deterioration of liver function. Pathological findings of the resected specimens revealed that all tumors were NET (G1, G2). We describe here a rare case of multiple NETs involving the small intestine treated by laparoscopic surgery.</p>

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