Abusing over-the-counter (OTC) drugs contained histamine H<sub>1</sub> receptor antagonist in a teenager with tonic seizure : A case report

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  • Nakatsuka Shun
    Emergency Medicine, Medical Center for Emergency, Yamagata Prefectural Central Hospital
  • Takeda Kenichiro
    Emergency Medicine, Medical Center for Emergency, Yamagata Prefectural Central Hospital
  • Morino Kazuma
    Emergency Medicine, Medical Center for Emergency, Yamagata Prefectural Central Hospital

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Other Title
  • ヒスタミンH<sub>1</sub>受容体拮抗薬を含有するOTC医薬品2剤の濫用により全身性強直性痙攣をきたした若年者の1例
  • ヒスタミンH₁受容体拮抗薬を含有するOTC医薬品2剤の濫用により全身性強直性痙攣をきたした若年者の1例
  • ヒスタミン H ₁ ジュヨウタイ キッコウヤク オ ガンユウ スル OTC イヤクヒン 2ザイ ノ ランヨウ ニ ヨリ ゼンシンセイ ゴウチョクセイケイレン オ キタシタ ジャクネンシャ ノ 1レイ

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Abstract

<p>An 18-year-old male who abused several over-the-counter (OTC) drugs, mainly diphenhydramine, was admitted to the emergency department. He presented with tachycardia, delirium, tremor, and tonic convulsions. He was treated with diazepam, tracheal intubation, and activated charcoal. His symptoms appeared to be caused by diphenhydramine poisoning. In addition, we suspected that the combined use of diphenhydramine, alcohol, and an anticholinergic agent exacerbated the poisoning symptoms. His symptoms improved with time and he was discharged on day 6.</p><p>In recent years, the routes for obtaining drugs and information are becoming more diverse. While OTC drugs are often readily available, we need to be aware that certain types of medication can cause serious symptoms.</p>

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