Male mediated developmental toxicity

YOKOTA Satoshi, OSHIO Shigeru

doi:10.51067/dohad.11.2_103

Bibliographic Information

Other Title

化学物質曝露により生じる雄性生殖機能障害と発生・発達毒性

Abstract

Less than 10% of drug-candidate compounds are associated with testicular toxicity. Therefore, developmental toxicity, such as paternally transmitted birth defects, is concerned if genetic abnormalities in the germ line persist and accumulate in the sperm during the spermatogenesis cycle. This paper will provide an overview of chemical and testicular toxicity and a forum for considering developmental toxicity from the perspective of male reproduction, which is often overlooked in the Developmental Origins of Health and Disease (DOHaD) discourse.

Journal

Developmental Origins of Health and Disease Research

Developmental Origins of Health and Disease Research 11 (2), 103-108, 2023-03-31

Japan Society for Developmental Origins of Health and Disease

Keywords

Details 詳細情報について

CRID: 1390014128337549696

DOI: 10.51067/dohad.11.2_103

ISSN: 21872597; 21872562

Text Lang: ja

Data Source

JaLC
KAKEN

Abstract License Flag: Allowed

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