Validating the G8 screening tool for determining the need for hematopoietic stem cell transplantation in elderly patients

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  • 高齢者に対する造血幹細胞移植の適応の判断におけるG8 screening toolの有効性の検証

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<p> Recently, allogeneic stem cell transplantation (allo-SCT) has increased in elderly patients due to the widespread use of reduced-intensity conditioning regimens and improved supportive care. However, physicians mostly determined indications empirically because it is difficult to judge the indication for allo-SCT in the elderly objectively.</p><p> We investigated the usefulness of the G8 screening tool, a simple test developed to identify older patients who could benefit from a comprehensive geriatric assessment, in determining the indication for transplantation in the elderly. Between January 2011 and December 2021, Fifty-four patients aged 65 years or older who underwent their first allogeneic stem cell transplant at our hospital were included. We examined the relationship between G8 screening tool scores and whether the patient was in-hospital dead or discharged. In patients who could be discharged, G8 screening tool scores were significantly higher than in patients in-hospital death. According to ROC curve, the cut-off value of the G8 screening tool score for predicting mortality is 10.0. In the analysis using this cut-off value, there was a significant difference in overall survival. The G8 screening tool score is useful in deciding whether or not to SCT an elderly patient and can be used to predict prognosis.</p>

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