Epithelial cell hyperplasia of the prostate may cause dysuria

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  • 前立腺の上皮細胞過形成は排尿障害を惹起する可能性がある
  • ゼンリツセン ノ ジョウヒ サイボウ カケイセイ ワ ハイニョウ ショウガイ オ ジャッキ スル カノウセイ ガ アル

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Abstract

Objective: The purpose of this study was to elucidate the histological characteristics of the prostate with induced dysuria in mice and to clarify the relationship with dysuria. Materials and Methods: Eight adult male C57BL/6J mice (mean age ± SD = 50.5 ± 3.7 wk) and 28 aged male C57BL/6J mice (mean age ± SD = 137.3 ± 21.2 wk) were used. Three uroflow parameters—voiding time, voided volume, and average flow rate—were determined in all mice from the uroflow curves. All the mice were sacrificed after 　the uroflowmetry examination to obtain the prostate specimen. The histologic examination of the prostate specimens was performed to evaluate prostatic hyperplasia. Epithelial area/gland area and epithelial cell density (= number of epithelial cells / epithelial area) were calculated for each gland. Results: The 28 aged male C57BL/6J mice were divided into two groups by uroflow profile: normal group (n = 22) and abnormal group (n = 6). A relationship between uroflow parameters and epithelial cell density in the gland was surveyed. In the dorsal lobe of the prostate, the epithelial cell density of the abnormal group was significantly higher than that of the normal group. We observed a significant negative correlation between epithelial cell density and uroflow parameters (voided volume and voiding time). Conclusions: We elucidated an inverse correlation between uroflow parameters (voided volume and voiding time) and epithelial cell density of the prostate. These results indicate that dysuria would be caused by epithelial cell hyperplasia of the dorsal lobe of the prostate.

Journal

  • 医療工学雑誌

    医療工学雑誌 (13), 1-8, 2019-03

    広島国際大学大学院医療・福祉科学研究科

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