Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives : In vitro and in silico Studies

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  • Yang Binfeng
    Department of Medical Oncology, Suzhou Ninth People’s Hospital·Suzhou Ninth Hospital Affiliated to Soochow University
  • Yuan Kaisheng
    Department of Gastroenterology, People's Hospital of Hongze District
  • Lu Ming
    Department of General Surgery-Gastrointestinal Surgery JiLin Central Hospital
  • El-Kott Attalla F.
    Department of Biology, College of Science, King Khalid University Department of Zoology, College of Science, Damanhour University
  • Negm Sally
    Department of Life Sciences, Faculty of Science and Art Mahail, King Khalid University Unit of Food Bacteriology, Central Laboratory of Food Hygiene, Ministry of Health
  • Sun Qiu ping
    Department of Chinese Medicine, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention
  • Yang Lu
    Department of Chinese Medicine, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University Department of Comprehensive Oncology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention

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  • Anti-cancer, Anti-collagenase and Anti-elastase Potentials of Some Natural Derivatives: <i>In vitro</i> and <i>in silico</i> Studies

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<p>The anti-cancer activities of the compounds were evaluated against KYSE-150, KYSE-30, and KYSE-270 cell lines and also on investigated esophageal line HET 1 A as a standard. Modified inhibitory impact on enzymes of collagenase and elastase were used Thring and Moon methods, respectively. Among both compounds, both of them recorded impact on cancer cells being neutral against the control, both had IC50 lower than 100 µM and acted as a potential anticancer drug. The chemical activities of Skullcapflavone I and Skullcapflavone II against elastase and collagenase were investigated utilizing the molecular modeling study. IC50 values of Skullcapflavone I and Skullcapflavone II on collagenase enzyme were obtained 106.74 and 92.04 µM and for elastase enzyme were 186.70 and 123.52 µM, respectively. Anticancer effects of these compounds on KYSE 150, KYSE 30, and KYSE 270 esophageal cancer cell lines studied in this work. For Skullcapflavone I, IC50 values for these cell lines were obtained 14.25, 19.03, 25.10 µM, respectively. Also, for Skullcapflavone II were recorded 20.42, 34.17, 22.40 µM, respectively. The chemical activities of Skullcapflavone I and Skullcapflavone II against some of the expressed surface receptor proteins (CD44, EGFR, and PPARγ) in the mentioned cell lines were assessed using the molecular docking calculations. The calculations showed the possible interactions and their characteristics at an atomic level.</p>

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