Incidence of Mid-Term Prognostic Events in Patients With Acute Coronary Syndrome During the Late 2010s in 2 Tertiary Hospitals in a Rural Area of Japan　― A Temporal Comparison ―

Yasuda Yu, Ishiguchi Hironori, Yamaguchi Madoka, Murakami Kei, Kinoshita Natsu, Kato Takayoshi, Yoshida Masaaki, Imoto Koji, Sonoyama Kazuhiko, Kawabata Tetsuya, Okamura Takayuki, Endo Akihiro, Kobayashi Shigeki, Yano Masafumi, Oda Tsuyoshi, Tanabe Kazuaki

doi:10.1253/circrep.cr-23-0029

Background: Data on the incidence of mid-term prognostic events in patients who developed acute coronary syndrome (ACS) in the late 2010s are scarce.Methods and Results: We retrospectively included and collected data for 889 patients with ACS (ST-elevation myocardial infarction [STEMI]/non-ST-elevation ACS [NSTE-ACS]) discharged alive from 2 tertiary hospitals in Izumo City, in rural Japan, between August 2009 and July 2018. Patients were divided into 3 time groups (T1: August 2009–July 2012; T2: August 2012–July 2015; T3: August 2015–July 2018). The cumulative incidence of major adverse cardiovascular events (MACE; comprising all-cause death, recurrent ACS, and stroke), major bleeding, and heart failure hospitalization within 2 years of discharge was compared among the 3 groups. The incidence of freedom from MACE was significantly higher in the T3 group than in the T1 and T2 groups (93 [95% confidence interval {CI} 90–96%] vs. 86% [95% CI 83–90] and 89% [95% CI 90–96], respectively; P=0.03). There was a tendency for a higher incidence of STEMI among patients in T3 (P=0.057). The incidence of NSTE-ACS was comparable among the 3 groups (P=0.31), as was the incidence of major bleeding and hospitalization for heart failure.Conclusions: The incidence of mid-term MACE in patients who developed ACS during the late 2010 s (2015–2018) was lower than that in prior periods (2009–2015).

Incidence of Mid-Term Prognostic Events in Patients With Acute Coronary Syndrome During the Late 2010s in 2 Tertiary Hospitals in a Rural Area of Japan　― A Temporal Comparison ―

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Incidence of Mid-Term Prognostic Events in Patients With Acute Coronary Syndrome During the Late 2010s in 2 Tertiary Hospitals in a Rural Area of Japan ― A Temporal Comparison ―

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Incidence of Mid-Term Prognostic Events in Patients With Acute Coronary Syndrome During the Late 2010s in 2 Tertiary Hospitals in a Rural Area of Japan　― A Temporal Comparison ―

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