Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve
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- Wang Jing
- Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China. The Academy of Integrative Medicine of Fudan University, Shanghai, China. Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
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- Pan Xinyao
- Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China. The Academy of Integrative Medicine of Fudan University, Shanghai, China. Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
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- Zhou Jing
- Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China. The Academy of Integrative Medicine of Fudan University, Shanghai, China. Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
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- Li Xin
- Urumqi hospital of traditional Chinese medicine, Urumqi, Xinjiang, China.
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- Sun Yan
- Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China. The Academy of Integrative Medicine of Fudan University, Shanghai, China. Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
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- Wang Ling
- Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China. The Academy of Integrative Medicine of Fudan University, Shanghai, China. Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases, Shanghai, China.
Abstract
<p>Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET), increasing cycle cancellation rates and reducing pregnancy rates. Although it is well known that dehydroepiandrosterone (DHEA) can be used as a dietary supplement for age-related diseases, its potential has gradually been shown for many diseases. In this review, we focus on the effects of DHEA on DOR, briefly analysing its clinical benefits and limitations and describing the mechanism of function and the clinical trials conducted. Therefore, we summarize the mechanisms and indications of DHEA for DOR. </p>
Journal
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 17 (2), 87-94, 2023-04-30
International Research and Cooperation Association for Bio & Socio-Sciences Advancement