Association between fat mass of trunk and limbs and arterial stiffness in hemodialysis patients

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  • Shuto Ayumi
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Okuno Senji
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Norimine Kyoko
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Okazaki Hisanori
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Ono Katsuhiro
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Taguchi Midori
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Yamakawa Kenjiro
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Shoji Shigeichi
    Department of Internal Medicine, Kidney Center, Shirasagi Hospital
  • Yamakawa Tomoyuki
    Department of Surgery, Kidney Center, Shirasagi Hospital
  • Mori Katsuhito
    Department of Nephrology, Osaka Metropolitan University Graduate School of Medicine
  • Emoto Masanori
    Department of Metabolism, Endocrinology and Molecular Medicine and Department of Nephrology, Osaka Metropolitan University Graduate School of Medicine

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Other Title
  • 血液透析患者における体幹および四肢脂肪量と動脈スティッフネスの関連
  • ケツエキ トウセキ カンジャ ニ オケル タイカン オヨビ シシ シボウリョウ ト ドウミャク スティッフネス ノ カンレン

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Abstract

<p>[Purpose] Previous studies reported that obese individuals exhibit increased arterial stiffness. Some demonstrated that fat distribution was a more pronounced determinant of arterial stiffness than general obesity. However, little is known about the relationship between fat distribution and arterial stiffness in patients with chronic kidney disease. The purpose of this study was to examine the association between fat distribution (fat mass of trunk and limbs) and arterial stiffness in hemodialysis patients. [Methods] Arterial stiffness of 609 hemodialysis patients (age, 68.0±12.3 years；hemodialysis duration, 7.7±7.5 years；male, 69.5％；diabetes, 33.5％) was assessed by brachial-ankle pulse wave velocity. The fat mass of the whole body, trunk, and limbs was measured using dual-energy X-ray absorptiometry. [Results] The median (IQR) pulse wave velocity was 1890 (1580-2236) cm/s. Age and systolic blood pressure were significantly and positively correlated with pulse wave velocity. The pulse wave velocity of diabetic patients was significantly higher than that of non-diabetic patients. There was no significant difference in pulse wave velocity between male and female patients. Multiple linear regression analysis showed that the trunk fat mass was significantly and positively correlated with pulse wave velocity, and limb fat mass was significantly and negatively correlated with pulse wave velocity, after adjustment for age, sex, hemodialysis duration, diabetes, and systolic blood pressure. The body mass index, total body fat mass, and percent body fat were not associated with pulse wave velocity. [Conclusion] These results suggest that increases in trunk fat mass and limb fat mass are both associated with arterial stiffness assessed by pulse wave velocity in hemodialysis patients.</p>

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