柑橘ポリフェノールのiPS細胞オートファジーへの影響
書誌事項
- タイトル別名
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- Effect of citrus polyphenols on autophagy in iPS cells
抄録
Somatic cells age and die over time, stem cells, being immortal cellular lineages, can persist indefinitely. The autophagy function of the cell declines over time, and with this decline, damage accumulates. The question of how the stem cell can avoid transmitting the damage to the next generation is a significant problem. Here we identified hesperidin, a citrus flavonoid, that promotes autophagy in induced pluripotent stem cells (iPSCs). We found that iPS cells whose proliferation was arrested in the presence of lemon extract exhibited stimulation of autophagy, including protein hydrolysis. Strikingly, lemon extract inhibited glycosylation of iPS cells following arrest of proliferation. The key to this reduction is the activation of β-glucosidase, a glycosidase present in lysosomes. Activated lysosomes promote a metabolic shift that mobilizes glycoproteins for degradation and resets proteostasis by clearing glycoproteins. Lemon hesperidin may stimulate autophagy activity in iPS cells through the TGF signaling pathway, a cytokine that blocks growth signals.
収録刊行物
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- 小山工業高等専門学校研究紀要
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小山工業高等専門学校研究紀要 55 (0), 26-33, 2022
独立行政法人 国立高等専門学校機構 小山工業高等専門学校
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390014879183708928
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- ISSN
- 24323500
- 02882825
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可